| Abstract Submission No. | ABS-2.2-0175 |
| Title of Abstract | Indian Seaweeds: Exploration for Marine Pharmaceuticals |
| Authors | Dr. Pramod B. Shinde* |
| Organisation | CSIR-CSMCRI, Bhavnagar |
| Address | CSIR-CSMCRI Bhavnagar, Gujarat, India Pincode: 364002 E-mail: pramodshinde@csmcri.res.in |
| Country | India |
| Presentation | Oral |
| Abstract | Seaweeds are increasingly recognized as valuable sources of nutrients and bioactive compounds with significant pharmaceutical potential. With the rising global incidence of diabetes mellitus and the limitations of current synthetic drugs, particularly their adverse side effects, there is an urgent need to explore safer and more natural therapeutic alternatives. In the present study, Indian seaweed species were examined for their phytochemical composition and antidiabetic potential. Extracts of these seaweeds were assessed for inhibitory activity against the key carbohydrate-hydrolyzing enzymes α-amylase and α-glucosidase. Seaweed extracts demonstrated promising antidiabetic effects. To identify the bioactive metabolites responsible for this activity, LC-MS and LC-MS/MS analyses were conducted, leading to the detection of diverse compounds. Novel metabolites with no prior reports of antidiabetic activity were subsequently selected for in silico molecular docking studies against four critical targets relevant to diabetes management: α-amylase, α-glucosidase, protein tyrosine phosphatase 1B (PTP-1B), and dipeptidyl peptidase-4 (DPP-4). Docking results revealed strong binding affinities, suggesting potential multitarget mechanisms of action. This was followed by formulation development using the seaweed extract exhibiting most promising profile. The prepared formulation was characterized for its physicochemical properties, providing a basis for further in vivo validation. This comprehensive investigation highlights the potential of Indian seaweeds as natural reservoirs of novel antidiabetic agents and supports the development of seaweed-based formulations for safer diabetes management. |
| Keywords | Seaweed; Antidiabetic potential; Metabolomics; in silico analysis; Formulation |